Ontological Turing's test

There ought to be, where the larger philosophical questions are concerned, a kind of ontological Turing's test. Take Substance. Say Aristotle was right all along; that there is such a thing. What difference does that knowledge make to us? If the answer is none: which is to say, if the Cosmos can convincingly give the appearance of functioning in a non-Substantive way -- then au revoir to that theory irrespective of its inherent rightness of wrongness. Surely.